Top 20 Granulation Interview Questions & Answers

Dry granulation is a powder agglomeration process used in the pharmaceutical industry to improve the flowability of powders by increasing the particle size (granules).
Roller compaction is a dry granulation process used to make coarse granules prior to final compression. Typical excipients used in roller compaction are Lactose, Microcrystalline Cellulose, and Magnesium Stearate as the lubricant.

Basic Principles Of Dry Granulation And Roller Compaction Technology. … Granulation is a process in which powder particles are made to adhere to each other, resulting in larger, multi-particle entities, so called granules. If such a process is performed without adding liquids, this is called dry granulation.

Dry granulation is a simple and low cost method, once extremely common and again becoming more popular because of its simplicity and cost efficiency. Dry granulation helps to increase the size of granules within powders, making it easier to form them into tablets or capsules.

Wet Granulation: The process of adding a liquid solution to powders involves the massing of a mix of dry primary powder particles using a granulating fluid. The fluid contains a solvent that must be volatile, so that it can be removed by drying, and be non-toxic.
Manufacture of Tablets by Direct Compression Method. … Today, the term direct compression (or direct compaction) is used to define the process by which tablets are compressed directly from powdered active drug substance and suitable excipients into a firm compact without employing the process of granulation.
Direct compression is a popular choice because it provides the shortest, most effective and least complex way to produce tablets. The manufacturer can blend an API with the excipient and the lubricant, followed by compression, which makes the product easy to process.


Granulation method can be broadly classified into two types: Wet granulation and Dry granulation. The most widely used process of agglomeration [1-7] in pharmaceutical industry is wet granulation.

Granulation is carried out for various reasons, one of which is to prevent the segregation of the constituents of powder mix. Segregation is due to differences in the size or density of the components of the mix. … Powdered sugar’s small particles have poor flow and compression characteristics.


Tablets are commonly manufactured by wet granulation, dry granulation or direct compression. These methods may be considered to consist of a series of steps (unit processes) – weighing, milling, mixing, granulation, drying, compaction, (frequently) coating and packaging.


Most challenging task while performing wet granulation in high-shear mixers, is the detection of end point and reproducibility of same end point by controlling various process variables. Endpoint can be defined by the formulator as a target particle size mean or distribution.

The process of granulation improves material properties such as flowability and compressibility and also avoids segregation of mixture components. … Fluid bed granulation is a wet granulation process that involves the addition of a binder liquid to primary particles to form aggregated granulates.

Granules.. lets say sand.. the particles are fine but small in size. Pellets.. you might have seen sodium hydroxide box in your school/college science (chemistry) labs. The shape of that one sodium hydroxide tablet is called pelletPellets are larger as compared to the above two.


It is much faster than the other strong compression tools ( bzip2 , lzma ), and some files it compresses even better than bzip2 or lzma . Yes, gz is the default compression tool on Linux. It is fast, and despite its age it gives still very good results in compressing text files like source code.


16) What is the difference between compaction and compression?
COMPRESSION Reduction in bulk volume of material due to displacement of gaseous phase.CONSOLIDATION Increase in mechanical strength of material due to particle-particle interaction.COMPACTION It is the compression & consolidation of two phases (solid & gas) system due to applied force.


17) Why granulation process is important prior to tablet compression?
Granulation and its importance in tablet manufacturing processGranulation process is an inevitable step in tablet manufacturing as it improves flow property and compressibility of powder mass intended for compressionGranulation prevents segregation of the constituents of the powder mix.

Neutrophils have two types of granules; primary (azurophilic) granules (found in young cells) and secondary (specific) granules (which are found in more mature cells).

The principle of Working: In rapid mixer granulator, the formation of granules occurs by rising, whirling and tumbling motion of the material. Dry mixing is done by adding all ingredients into the RMG by rotation of impeller and chopper at high speed.


Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. Granulation process transforms fine powders into free-flowing, dust-free granules that are easy to compress.
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